Glycyrrhizic acid, monoammonium salt trihydrate
glycyrrhizic acid monoammonium salt
CAS: 53956-04-0
Molecular Formula: C42H65NO16
Glycyrrhizic acid, monoammonium salt trihydrate - Names and Identifiers
Glycyrrhizic acid, monoammonium salt trihydrate - Physico-chemical Properties
| Molecular Formula | C42H65NO16 |
| Molar Mass | 839.97 |
| Density | 1.1846 (rough estimate) |
| Melting Point | >200°C (dec.) |
| Boling Point | 768.56°C (rough estimate) |
| Flash Point | 556.6°C |
| Solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Powder or Crystals |
| Color | Yellow to yellow-green |
| BRN | 3897076 |
| Storage Condition | 2-8°C |
| Refractive Index | 49 ° (C=1.5, EtOH) |
| Physical and Chemical Properties | White needle crystal or crystalline powder, with a strong sweet taste, sweetness of sucrose 50~100 times. The melting point was 208-212 °c. Soluble in ammonia, insoluble in acetic acid. Mouse oral LD50 greater than 10 g/kg. |
| Use | The pharmaceutical industry is used for cough and phlegm, the treatment of liver disease, etc |
Glycyrrhizic acid, monoammonium salt trihydrate - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | LZ6500000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29389090 |
Glycyrrhizic acid, monoammonium salt trihydrate - Nature
Open Data Verified Data
White needle crystal or crystalline powder, with a strong sweet taste, sweetness of sucrose 50~100 times. The melting point was 208-212 °c. Soluble in ammonia, insoluble in acetic acid.
Last Update：2024-01-02 23:10:35
Glycyrrhizic acid, monoammonium salt trihydrate - Preparation Method
Open Data Verified Data
crude glycyrrhizic acid as raw material, acidic ethanol as extractant, refined.
Last Update：2022-01-01 10:10:18
Glycyrrhizic acid, monoammonium salt trihydrate - Use
Open Data Verified Data
China's provisions can be used for beverages, flavors, biscuits, candy, preserved fruit and canned meat, according to the production needs of the appropriate amount of use.
Last Update：2022-01-01 10:10:18
Glycyrrhizic acid, monoammonium salt trihydrate - Reference Information
| Plant source: | Licorice |
| FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| LogP | -0.9 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | ammonium glycyrrhizinate has a strong sweet taste and is about 200 times as sweet as sucrose. it can usually be used as a sweetener in food additives for canned meat, seasonings, candies, biscuits, cold fruits and beverages. Monoammonium glycyrrhizinate has a strong affinity for liver sterol metabolism enzymes, which hinders the inactivation of cortisol and aldosterone. After use, it shows obvious corticosteroid-like effects, such as anti-inflammatory effects, anti-allergic effects and protective film structure.; No obvious corticosteroid-like side effects. |
| action | this product can promote bile pigment metabolism and reduce ALT and AST release; Induce γ-IFN and interleukin II, increase NK cell activity and OKT4/OKT8 ratio and activate reticuloendothelial system; Inhibit histamine release from mast cells; Inhibit the formation of cell membrane phospholipase A2(PL-A2) and prostaglandin E2(PGE2) and granulomatous reaction; inhibit the production and formation of free radicals and lipid peroxides, reduce the activity of proline hydroxylase; regulate calcium ion channels, protect lysosomal membranes and mitochondria, reduce cell damage and necrosis; promote epithelial cells to produce mucopolysaccharides. |
| content determination | a method for determining the content of ammonium glycyrrhizinate in yinma jiedu granules aims to provide a method for determining the content of ammonium glycyrrhizinate with high detection accuracy and reliable detection results; The method is: 1) weigh 1g of yinma jiedu granules, add 10g of diatomite and mix evenly for later use; 2) extraction; 3) Transfer the extract to an evaporation dish, evaporate and dry, dissolve with acetonitrile and fix the volume to a 10mL volumetric flask, absorb 2ml of sample liquid and add it to a centrifuge tube for purification, and inject the solution into a liquid meter for determination after passing through a 0.22 micron filter membrane; 4) Parameter setting for analysis by liquid chromatography; Belongs to the technical field of chemical detection. |
| Application | Ammonium glycyrrhizinate can also form a compound preparation. The combined compound preparation of ammonium glycyrrhizinate, glycine, and L-cysteine hydrochloride has adrenocortical hormone-like effects, but no hormone-like side effects; and exerts its anti-inflammatory and anti-allergic effects through various ways such as stabilizing cell membranes and antagonizing allergic mediators; it can also be used for detoxification, viral hepatitis and adjuvant treatment of tumor radiotherapy and chemotherapy. Can be used for allergic diseases: eczema, urticaria, rheumatism, allergic asthma and sulfonamide, narcotics and other drugs caused by allergies. |
| use | China's regulations can be used for beverages, seasonings, biscuits, candies, cold fruits and canned meat, and should be used appropriately according to production requirements. Flavoring agent; Flavoring agent; Surfactant. The pharmaceutical industry is used to relieve cough and phlegm, treat liver disease, etc. Bioactive components of sweet roots of licorice. Anti-virus. |
| production method | the root and rhizome of licorice (see "02317") are precipitated with acid, neutralized by dilute ammonia solution and dried. Appropriate diluent can be added. using crude glycyrrhizic acid (content about 50%, gravimetric method) as raw material and acidic ethanol as extraction agent, refined and obtained. 50g of crude glycyrrhizic acid was added to 170mL of 95% ethanol acidified by hydrochloric acid (Ph value 3.5~4.0), and stirred and extracted at 40~50 ℃ for 4 hours. After filtration, the filter residue was extracted with 100mL ethanol under the same conditions for 3h. Combine the extracts, add ammonia water or ammonia gas dropwise under stirring to make the Ph value of the solution 7.2~7.5, and let it stand for 0.5h at room temperature to completely precipitate. Precipitate into glycyrrhizic acid triammonium salt, with a proper amount of glacial acetic acid to disperse into paste, if necessary, slightly heated, standing for 1h after filtration, to convert it into an ammonium salt. After crystallization separation, wash with a small amount of glacial acetic acid for 1~2 times to obtain light yellow crude product. Decolorization and recrystallization of activated carbon with 75% ethanol to obtain 15.5g of white crystal with 61% yield and purity ≥ 98%. |
Last Update：2024-04-09 15:16:46
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